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Question: 1 your patient is suffering from anemia sickle cell might...

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1. Your patient is suffering from anemia. Sickle cell might be the cause.

a. Explain why DNA microarray might be used to confirm or reject the diagnosis of sickle cell disease.

b. The hospital where you work has all the necessary equipment (DNA microarray). Explains the different steps that the lab technician will take to conduct the test

c. Explain how the test works.

d. Explain the possible outcomes, what the different colors tell you, and how to interpret the results.

2. You are an investigator and interested in Tay–Sachs disease and would like to use a mouse model.

a. Explain the condition.

b. Explain why using a knock-out mouse seems to be an appropriate technique to study the disease.

c. Explain the breeding scheme that results in a heterozygous “Tay-Sachs” mouse.

d. Although it seems to be a good idea; it has been shown that it doesn’t work well. Why? (consultation of the literature is required).

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