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  3. 12 vesidles of the sarcoplasmic reticulum have embedded in their...

Question: 12 vesidles of the sarcoplasmic reticulum have embedded in their...

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12. Vesidles of the sarcoplasmic reticulum have embedded in their membrane an active Ca ATPase pump. Several different isoforms of this primary active pump are expressed in different to ATP, Mg, and Ca tissues. When exposed 2+ Ca ions are accumulated and eventually reach a steady-state uptake. If the pump is quickly quenched by adding extravesicular EGTA, which complexes activator Ca and thereby stops the pump, the accumulated Ca w leak back out. Monitoring the intravesicular Ca with time allows one to estimate the permeability of the vesidles. Derive an expression for the amount of Ca remaining in the vesicle as a function of time and suggest a plot to determine the perme- ability. What other information might you need to know to determine the permeability? 2+ 2+

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