Question: 2 you are an investigator and interested in taysachs disease...
2. You are an investigator and interested in Tay–Sachs disease and would like to use a mouse model.
- Explain the condition.
- Explain why using a knock-out mouse seems to be an appropriate technique to study the disease.
- Explain the breeding scheme that results in a heterozygous “Tay-Sachs” mouse.
- Although it seems to be a good idea; it has been shown that it doesn’t work well. Why? (consultation of the literature is required).