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Question: 4 a lysine residue near the periphery of a proteinprotein...

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4. A lysine residue near the periphery of a protein-protein interface is mutated to alanine and changes the Ko of binding from 2 nM to 2 uM at 300 K. a) How much binding energy was contributed by that residue? b) What is the likely nature of this interaction given the structure and properties of lysine vs. alanine? c) Would you expect a similar change when lysine is mutated to arginine? Justify your answer briefly.
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