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  3. 5iron homeostasis is critical to the mammalian organism a outline...

Question: 5iron homeostasis is critical to the mammalian organism a outline...

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5.Iron homeostasis is critical to the mammalian organism.

(a) Outline the features of iron-mediated regulation of transferrin receptor and ferritin, and indicate the roles of these two proteins in iron homeostasis. Indicate what effects the following mutations of aconitase would have on the level of the transferrin receptor and ferritin proteins:

(b) a mutant aconitase with a 10X higher affinity for iron than the wild type aconitase

(c) a mutant aconitase with a 10X lower affinity for iron than the wild type aconitase

(d) a mutant aconitase with a 10X higher affinity for the IRE than the wild type aconitase

(e) a mutant aconitase with a 10X lower affinity for the IRE than the wild type aconitase

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