1. Science
  2. Biology
  3. 5o the first reaction in glycolysis is the phosphorylation of...

Question: 5o the first reaction in glycolysis is the phosphorylation of...

Question details

5.O The first reaction in glycolysis is the phosphorylation of glucose This is a thermodynamically unfavorable pracess, with AG +13.8 kJ /mol. a. In a liver cell at 37C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate, according to the above data? b. This very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reaction k] ATP +glucose glucose 6 phosphate + ADP+Ht AG ATP Hydrolysis 32.2 Aco mol What is AG for the coupled reaction? c. If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration -3 mM and ADP concentration-1 mM, what is the theoretical concentration of glucose. 6-phosphate at equilibrium at pH-74 and 37 C? The answer you will obtain is an absurdly high value for the cell and in fact is never approached in reality. Explain why

Solution by an expert tutor
Blurred Solution
This question has been solved
Subscribe to see this solution