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  3. a an enzyme that contains 450 amino acids has a...

Question: a an enzyme that contains 450 amino acids has a...

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A) An enzyme that contains 450 amino acids has a binding site for its substrate at positions 186 and  187, which are K residues. The receptor binds the molecule Dirt, a peptide of 55 amino acids, that contains E-E at positions 24 and 25.  The enzyme does not bind the Dirt at pH 3.0 or 12.  Which of the following bestexplains the reason for the lack of binding? Draw it to make sure.

  1. At pH 3.0 Dirt is positively charged, K is positively charged so there is no binding.  At pH 12 Dirt is neutral, while K is neutral so no binding.
  2. At pH 3.0 Dirt is neutral, K is positively charged so no binding.  At pH 12 Dirt is neutral, while K is positively so no binding.
  3. At pH 3.0 Dirt is neutral, K is positively charged so no binding.  At pH 12 Dirt is negatively charged, while K is neutral so no binding.
  4. At pH 3.0 Dirt is neutral, K is neutral charged so no binding.  At pH 12 Dirt is negatively charged, while K is negatively charged so no binding.
  5. At pH 3.0 Dirt is neutral, K is neutral so no binding.  At pH 12 Dirt is negatively charged, while K is neutral so no binding.

B) What type of bonds are most likely responsible for the binding of the enzyme to its substrate, Dirt, at pH 7.4 in question B?

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