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Question: cells can generate resting membrane potentials which are essential to...

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Cells can generate resting membrane potentials, which are essential to secondary active transport mechanisms, excitability, and generation of action potentials. The resting membrane potential of a cell is determined by which ions it actively pumps across the membrane (and in which direction) and to what extent the ions can leak back across the membrane down their electrochemical potential gradient. Suppose a muscle cell has a resting membrane potential that is primarily determined by the transport of K, Nat, and CI. The cell actively pumps Nat and Cl out and pumps K* in. Passive leakage (permeability) of Nat across the membrane is very low, while the permeability of K is about 10 times that of Na 2. The following are the concentrations of these ions inside and outside of the cell: lon Extracellular Fluid (mM Cvtoplasm (mM 122 2.5 122 [Na] 140 [CI] The resting membrane potential for this cell at 37°C is experimentally found to be -86 mV. Determine the permeability of Cl- of the cell relative to that of Nat. At this temperature, the quantity RT/F is equal to 26.72 mV and the membrane potential equation is: RT P CI CI e In Na Nat Cc In this equation, e subscripts indicate outside the cell (extracellular) and i subscripts indicate inside the cell (intracellular). Note that this is the same equation given at the end of the corresponding slide deck

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