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Question: explore the available literature to characterize possible drugdrugjuice interactions that...

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Explore the available literature to characterize possible ‘Drug-Drug/Juice interactions’ that might occur when the following concurrent administration of drugs or with intake of a juice (1 point each). List at least one source of literature where this interaction has been studied in human beings and reported. Students are encouraged to refer to the original research articles, where applicable. If you believe no significant interaction exists, justify by providing adequate explanation.

a. Fentanyl and ketoconazole

b. Methadone and ‘grapefruit juice’

c. Oxycodone and ritonavir

d. Tramadol and bupropion

Below is an example of how to answer the question

[For example Meperidine and Phenytoin: Concurrent administration of these two drugs would result in pharmacokinetic, specifically metabolic, drug interaction. Phenytoin is a CYP2D6 inducer. Rapid metabolism of meperidine would result in decreased plasma levels of meperidine and increased concentrations of normeperidine. This metabolite is neurotoxic and may likely precipitate tremors.]

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