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Question: family tree cystic fibrosis man with cystic fibrosis woman...

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Family tree - Cystic fibrosis Man with cystic fibrosis Woman with cystic fibrosis Woman without cystic fibrosis Man with out cystic fibrosis Rob Jane Leon ClaireOwen Shane Paula Keith David Laura Sian
The attached file contains a Caucasian family pedigree showing some of the members with a diseases named Cystic Fibrosis. Cystic Fibrosis is observed in 1/2500 live births. In Caucasians mutant alleles are observed in a frequency of 0.025 (1 mutant chromosome/40 total chromosomes) You know this family, and also you know that David and his uncle Leo will marry daughter and mother respectively from a different family, which family history is totally unknown. They know that you are a biologist, so they wondering if you can predict for them the odds of getting a sick child with Cystic Fibrosis.
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