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Question: fragmentbased lead discoverydrug design is method by which small components...

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1.- Fragment-based lead discove drug design is method by which small components are identified that interact with (bind to) regions of the receptor ligand binding pocket. The individual binding interactions may either overlap or be adjacent to one another, suggesting that a combination of fragments would lead to a higher affinity agent capable of fulfilling the biological criteria. Shown below is a set of three fragments identified in screening assay against a target receptor. Without describing the specific chemistry, show a strategy that you woulduse to assemble a molecule that would include all three fragments. OH HO HN NH

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