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Question: imagine two toxins called x and y both toxins resemble...

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Imagine two toxins called “X” and “Y”. Both toxins resemble bile salts. They travel from the blood into liver cells via the same organic cation transporter (OCT) and leave the cell via the same ABC Transporter. One of the toxins causes damage inside the liver cells, the other acts in the bile canaliculus (tube in which bile collects after being excreted from cells).

a. Scientists measure the affinity of X and Y for the OCT and ABC transporter that they use in liver cells. Which toxin is likely to do damage from inside the cells? Which in the bile canaliculus? Explain your answer.

OCT Kd (HM) 2.3 2.5 ABC trans. Kd (μΜ) 0.05 22.1 Toxin

b. Scientists identify an inhibitor of the OCT used by these toxins. If the inhibitor is given to a patient along with toxin X or toxin Y, what will happen in each case? Explain your answer.

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