Question: pharmacologyandnbspscenarioandnbspandnbspleo went to his doctor who informed him that there...
Leo went to his doctor who informed him that there is no point in using excessive doses of Ventolin®. The doctor explained that when frequent, large doses of Ventolin® are inhaled, the drug is absorbed from the lung into the circulation in sufficient amounts to have unwanted effects on the heart (rapid rate) and the muscles (tremor). The doctor asked Leo how often he was using his inhaled corticosteroid. When Leo confirmed that he was taking it regularly twice a day, the doctor decided to increase the dose of the inhaled corticosteroid in the expectation that this will control the asthma. Leo's doctor also switched Leo to a new asthma medication that has higher affinity for the b2-adrenoceptors compared with Ventolin®.
Alternative therapies for asthma might be more appropriate in place of or in addition to short acting b agonists like salbutamol. In Joe’s case he also takes a corticosteroid inhaler. What is the mechanism of action of the corticosteroid in asthma? You may explain using diagrams if you wish (2.5 marks)