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Question: probability and genetic counseling pedigrees can be used to identify...

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Probability and Genetic Counseling Pedigrees can be used to identify the likely mode of inheritance of traits and predict the probabiliay of traits in otfspning of proposed matings. Often phenotypes of individuals in pedigrees are known but exact genotypes may not be known for some individuals. The rules of probabality we have sruched thus far apply in determining the chance of a child having a certain genorype or phenotype If the trait is a disease or if one is concerned about the chance of being a genetic carrier, then one could consider the probabalities of genetic risk associated with the disease. Analyze the four generation human pedigree below for the red hair trait. Mark all genotypes, to the extent that is possible, on the identical second pedigree diagram. Then determine the probability of a red-haired child for the cight matings that are proposed on the next page. Here are the assumptions you should make: (1) mutation changing the alleles is rare (probability 0 withim this small pedigree), (2) persons joining the pedigree from outside the direct genetic line are homorygous dominane unless otherwise indicated by pedigree designation, trait expression, or inference from the pedigree, and (3) all hair color indicated in the pedigree is naturally occurring, Filled symbols represent individuals with red hair. For the hair color alleles use RR and Rr (not red) and rr (red) to denote genorypes Rr RP edigree legend 12 134 15 6 TY 1 IV TY1 2 111 品占 IV 6YSX
Proposed matings: 111-5 x III.u- (Ix戈) x (⅔xk) :// 3. 111.9 x 111-18- 111-3 x 111-14 = 5. 111-10x111-11 = o24 7. IV-4x I1I-9 Gambling with Genetics worksheets were adapted from: Moore, S. A. 2009. Gambling with genetics: An introduction to probability and Chi Square analysis. Pages 302-309, in Tested Studies for Laboratory Teaching, Volume 30 (K.L. Clase, Editor). Proceedings of the 30th Workshop/Conference of the Association for Biology Laboratory Education (ABLE), 403 pages
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