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Question: sterol regulatory element binding proteins srebps are large proteins embedded...

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Sterol regulatory element binding proteins (SREBPs) are large proteins embedded in the endoplasmic reticulum membrane as inactive precursors. Place the steps describing the activation of SREBP and subsequent transcriptional activation of target genes in the order that they occur. SREBP activation (5 items) Drag and drop into the appropriate area) Order of steps Inactive precursor Cholesterol binding to regulatory domain decreases. ER-bound precursor complex is disrupted Proteolysis occurs, releasing SREBP DNA binding domain. 2 Precursor SREBP is escorted to the Golgi apparatus. SREBP is translocated to the nucleus 3

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