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Question: the administration of an ivbolus containing 10 mg of cocaine...

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The administration of an iv-bolus containing 10 mg of cocaine hydrochloride (MW cocaine hydrochloride = 340 g/mol; MW cocaine = 303 g/mol) to a subject results in an area under the plasma concentration curve (AUC) of 70 μg/L/hr. Calculate total body clearance in this subject.

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