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Question: the plasticizer di2ethylhexyl phthalate dehp is used widely in synthesizing...

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The plasticizer di-(2-ethylhexyl) phthalate (DEHP) is used widely in synthesizing plastics. Due to its heavy use and its ability to leak out of plastic products, it is important to analyze its potential to be toxic in humans.

c. Guinea pigs have very low levels of PPARa protein in their liver cells. They do not develop liver tumors upon exposure to DEHP. Is this difference due to a toxicokinetic or toxicodynamic effect? Explain.

d. Humans also have very low levels of PPARa in the liver. Imagine that you are charged with making recommendations on the safety guidelines for DEHP. What would you recommend? Why?

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