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  3. this published table summarizes the clinical trial results for a...

Question: this published table summarizes the clinical trial results for a...

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This published table summarizes the clinical trial results for a colon cancer drug, panitumumab (Vectibix™). The experimental group is summarized in the middle column, described as P + BSC, i.e., experimental drug (panitumab) plus best supportive care (BSC). The far right column is the control group, who received the best supportive care (BSC) without the experimental drug.

The drug study data in Table 3 is “statistically” significant. What does that term mean, precisely?

Consider the difference between the medians for the two groups (this difference would normally be the relevant comparison for such drugs); is the difference between the medians “clinically significant?” Why or why not? How does your answer here differ from the answer about statistical significance?

Expiremental

Control

Median

56

51

95% ci

55-59

50-54

Mean (sd)

96.4 (5.3)

59.7 (3.75)

Min, max

0, 357

0, 337

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