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Question: when cytosine is deaminated to uracil see figure above which...

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When cytosine is deaminated to uracil (see figure above). which can then base pair with adenine, some DNA polymerases wont read uracil. However, mammalian DNA polymerases cant distinguish uracil from thymine. If uracil is not removed, how can that DNA lesion cause a mutation? Fill in the boxes. (Ilmage adapted from Connolly. Biochem. Soc. Transactions 37(1):65-68 (2009).) deamination replication replication

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