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  3. you believe that the axons required to form connections between...

Question: you believe that the axons required to form connections between...

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You believe that the axons required to form connections between the eye and the brain are guided by Wnt signaling excreted from the brain.

1.What are TWO ways you can demonstrate that Wnt signaling is involved the in the eye axons (retinal ganglion cells) reaching the brain region (optic lobe)

2.How could you verify the “canonical” pathway was required? (the pathway on the bottom)

3.How could you verify it was specifically the canonical pathway?

Wnt--> Frizzled/LRP5/6--> Disheveled--| GSK3--| B-catenin--> Transcription--->

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