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Question: you discover that children from families living in an isolated...

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You discover that children from families living in an isolated village have a high level of anemia. Some have a mutation in a novel gene (not the gene in (2) above), but some don't. Not a lot is known about this gene. You are not sure if this gene is causing the anemia, or an environmental factor could be to blame. You suspect that heavy metal contamination of the water supply could be acting as a teratogen to cause anemia. Using the mouse as a model, how might you test the roles of this gene and the heavy metals (if any) in causing anemia? (4 marks)

You find that heavy metal contamination causes anemia in the mouse model, not the gene found to be mutated (which was a non-causative coincidence). Name three aspects that you must consider in establishing the susceptibility of the children to heavy metals as teratogens. (2 marks)

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